HbA2 Controls for
Minor Trait Testing
The normal adult blood level of HbA2 ranges from about
1.4% – 3.2%.
However in cases of β-thalassemia, where there is a deficit in production of β – chains, the levels of HbA2 can be elevated above 3.5%. Hence the measurement of an elevated HbA2 blood level has become the single most important diagnostic test to identify carriers of the β-thalassemia trait.
The Trilevel HbA2 levels are:
Level 1: 2.0 – 3.2
Level 2: 3.5 – 4.0
Level 3: 5.5 – 7.5
The total Hb concentration of the lyophilised control is 90 – 110g/L.
The controls are a set of bilevel or trilevel lyophilised controls that cover the patho-physiological range. They have an unopened shelf life of 3 years stored at 2°C – 8°C with open vial stability of 4 weeks. They are suitable for the main methods used to quantify HbA2 including Cellulose Acetate Electrophoresis with elution of the separated bands, Anion-exchange Micro Column Chromatography, Automated High Performance Liquid Chromatography and Capillary Electrophoresis.
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